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  • T Cells and the Regulation of Herpes Simplex Virus Latency and Reactivation
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  • HSV infects epithelial cells in the mucosa or skin, then enters peripheral nerve endings and travels intraaxonally to the sensory...
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Document Cd8aa t cells herpes dating Share Science Spotlight. Genital herpes is one of the most common chronic viral infections in the world. Herpes simplex virus 2 HSV-2 causes the vast majority of cases of this sexually-transmitted disease, whereas HSV-1 is the herpesvirus type typically associated with cold sores in and around the oral mucosa. Once a person is infected with genital herpes, a quiescent source of HSV-2 persists in the cell bodies of the sensory neurons that project from the genital tract to the spinal cord. For the rest of their lives, infected individuals will experience HSV-2 reactivations, in which herpes viruses arise from this dormant neuronal source and infect keratinocytes in the genital tract. These recurrent HSV-2 episodes can involve painful lesions in and around the genital tract, or they can be totally asymptomatic yet still be infectious to others. Herpes has no cure.
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